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Heparin, Buy Heparin Online
Brand names: Hep-Pak, Heparin Lock Flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage.
Generic Name: heparin (HEP a rin).
Heparin is a member of the medicine groups known as anticoagulants. A question appears: what is the function of an anticoagulant? The action of anticoagulants is discontinuing coagulation; in other words, anticoagulant stops blood from clotting. But anticoagulant is not able to diminish the volume of the blood clots which have been already developed. It is necessary to mention that this drug has other functions too. The most significant purpose of this medicine is to fight against invading bacteria and other foreign compouns.
This medication is given by injection into a vein or under the skin (subcutaneously). It must not be injected into a muscle.
Structure of Heparin
Heparin consists of a variably sulfated repeating disaccharide unit. The most usual disaccharide unit consists of a 2-O-sulfatediduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). For example, it makes up 85% of heparins from beef lung and about 75% of those from porcine intestinal mucosa.
The main sugars which occur in this preparation are listed below:
α-L-iduronic acid 2-sulfate;
2-deoxy-2¬sulfamino-α-D-glucose 6-sulfate;
β-D-glucuronic acid;
2-acetamido-2-deoxy-α-D¬glucose;
α-L-iduronic acid.
The sugars enumerated above are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5). This preparation is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups.
Mechanism of action of heparin
It has been already noticed that heparin stops blood from clotting. How does it act? It neutralizes thrombin. In order to inactivate thrombin this medicine binds itself to the coagulation enzyme and antithrobin. The activated antithrombin inactivates thrombin and other proteases caused blood clotting. So, wee understand that antithrombin prevents coagulation by neutralizing proteins that are involved in the coagulation cascade.
Administration of Heparin
Heparin is utilized in case of dialysis, during extracorporeal circulation ardiopulmonary bypass for heart surgery.
This medication is utilized to cure people with following diseases:
peripheral occlusive disease;
thromboprophylaxis;
acute coronary syndrome;
atrial fibrillation;
deep-vein thrombosis and pulmonary embolism.
Heparin dosage
The recommended dose of heparin depends on some factors. The dose is depends on the coagulation test results. These tests should be done very frequently. The determination of coagulation time henges on some conditions. When heparin is administrated by continous intravenous infusion, the coagulation tests have to be done approximately every 4 hours in the early stages of treatment. When the drug is administered periodically by intravenous injection, coagulation tests are to be performed before every injection during the early stages of treatment.
In case of deep vein Thrombosis – Prophylaxis common the recommended dose is 5000 units under the skin every 8 to 12 hours.
Usual dose for anticoagulation in case of pregnancy is 5000 units subcutaneously every 12 hours.
Usual adult dose for thrombotic disorder is100 units/mL each 6 to 8 hours for PVC catheters and peripheral heparin locks. But when stagnant blood is noticed in catheter after it was utilized for medication or blood administration, it is necessary to add flushes. The dose for babies who have got thrombotic disorder is 10 units every 6 to 8 hours. Child dose in this case is 100 units/mL each 6 to 8 hours. Additional flushes should be administrated when stagnant blood is noticed in catheter, after catheter is used for medicine or blood administration.
If a person suffers of a severe pulmonary embolism, the initial dose may be an IV bolus of 10,000 units which are followed by 1500 units per hour.
Potentional negative effects of heparin
Heparin, as every medicine is able to lead to side symptoms. A lot of patients utilizing this product do not have severe negative effects. Some common negative consequences of this medicine are following: swelling at injection site, bone pain, easily broken bones. Pain and loss of feeling in the arms and legs, change in color of the arms and legs, chest pain, difficult breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
Heparin can lead to some other unwanted reactions: signs of severe bleeding, including unusual pain, swelling, discomfort, prolonged bleeding from cuts, continous nosebleeds, unusually heavy and prolonged menstrual periods, unusual easy damages, dark urine, black stools, serious headache, unusual dizziness.
Severe allergic reactions were registered rarely, but sometimes they may be caused. If you use this medicine and observe such symptoms as rash, itching, swelling, serious dizziness, difficult breathing and others, consult your doctor.
There are such adverse symptoms that are caused in case of long-term Heparin administration; others can be results of a systematic using of heparin. For example, osteoporosis can be caused by long-term administration of high dosages of this product, cutaneous necrosis has been noticed after systemic utilizing; suppression of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on discontinuation of this drug have also been noticed.
Important elevations of aminotransferase levels have occurred in a high percentage of patients and healthy subjects who have received this medicine.
Coumadin and Heparin
Coumadin and Heparin are anticoagulants, so they both stop blood from clotting. They are utilized to treat such conditions as embolism and thrombosis. However they sound similar, coumadin and heparin have a lot of differences. As for utilizing them, coumadin is used orally, heparin is administratedin a form of injection. Coumadin must not be taken by pregnant women, heparin may be used by pregnant women. Coumadin and heparin may lead to excessive bleeding that may be life-threatening.
Heparin recall
Firstly, let metion what medicine recalls are. Medication recalls are such acts that are done in order to remove some medications from the market.
As for Heparin, the most of recalls were in 2008 as a result of unwanted results of heparin which was produced in China.
But there were no any recalls related to heparin that was manufactured by B. Braun Medical Inc. B.Braun producer advices to discontinue heparin use and contact your prescriber, if any negative results occur.
Heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a form of thrombocytopenia which was developed as a result of administration of heparin. So, it is a undesirable effect which was produced by heparin use. There are two types of Hit: type 1 and type 2. HIT type 2 is a more severe adverse consequence than HIT type 2. HIT type 2 can be a fatal aspect. In order to confirm that a patient has HIT, he must do specific laboratory tests.
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